Phosphodiesterase 9 (PDE9) regulates bovine tracheal smooth muscle relaxation
نویسندگان
چکیده
منابع مشابه
Phosphodiesterase 9 (PDE9) regulates bovine tracheal smooth muscle relaxation
The present study was designed to clarify phosphodiesterase 9 (PDE9) expression in bovine tracheal smooth muscle tissue, and to elucidate that PDE9 may contribute to the regulation of airway relaxation. PDE9 mRNA expression was detected in bovine tracheal smooth muscle. Sodium nitroprusside (an NO donor) and BAY 73-6691 (a selective PDE9 inhibitor) reduced high K+- and carbachol-induced contrac...
متن کاملM2 muscarinic receptors inhibit forskolin- but not isoproterenol-mediated relaxation in bovine tracheal smooth muscle.
The ability of the M2 muscarinic receptor to inhibit the relaxant effects of forskolin and isoproterenol was investigated in bovine trachea. In most experiments, we measured contractile responses to oxotremorine-M in smooth muscle isolated from bovine trachea in which a majority of M3 receptors were inactivated by treatment with N-(2-chloroethyl)-4-piperidinyl diphenylacetate. In the presence o...
متن کاملMyosin phosphorylation during contraction and relaxation of tracheal smooth muscle.
The role of myosin phosphorylation in regulating smooth muscle contraction has been investigated by quantitating the myosin phosphate content of tracheal smooth muscle frozen during contraction or relaxation. Myosin was purified from quick-frozen muscle samples with the aid of antibodies prepared against tracheal smooth muscle myosin, and the phosphate content was determined after separation of...
متن کاملMechanism of capsaicin-induced relaxation in equine tracheal smooth muscle.
The effects of capsaicin and neuropeptides were examined in equine tracheal smooth muscle (TSM). Neither capsaicin nor substance P (SP) contracted TSM. Capsaicin (100 μM) elicited relaxation in TSM contracted with methacholine. This relaxation was not mimicked by SP or calcitonin gene-related peptide (CGRP). Relaxation was not attenuated by removal of the epithelium or by pretreatment of tissue...
متن کاملAirway smooth muscle relaxation.
Bronchodilators are important agents in the treatment of asthma and chronic obstructive airways disease. Beta agonists, theophyllines, and antimuscarinic agents are the main drugs in current use, but others are under investigation. Although other actions may be important, these drugs produce bronchodilation either by a direct effect on airway smooth muscle or by inhibiting neural pathways. As o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Veterinary Medical Science
سال: 2018
ISSN: 0916-7250,1347-7439
DOI: 10.1292/jvms.18-0011